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Psychoactive cannabinoids

The group of molecules called cannabinoids gets their name from their ability to bind or indirectly affect the cannabinoid receptors of the endocannabinoid system. They are among the most important compounds in the cannabis plant.

The main cannabinoids
The development of cannabinoids is very varied. The genetics of a particular species is the determining factor in this. One species is very rich in THC and the other more in CBD. There are many more of these molecules. Some occur in higher concentration than others. The main cannabinoids will be mentioned below.

• THC is the main strain. These cannabinoids bind to the CB1 and CB2 receptors of the endocannabinoid system. As may be known to most, THC has a major influence on, among other things, appetite and mood after consumption.
• The second most important cannabinoid in most cannabis strains is CBD† This cannabinoid has the upper hand when it comes to the hemp plant. For most consumers, the use of cannabidiol results in a clear and relaxed effect. It has a low affinity with the cannabinoid receptors. In addition, it has an indirect influence on the endocannabinoid system. To this day, the effects of CBD are promising. This is why it is so popular as food supplement.
• Often CBC only makes up 0,3% of the total cannabinoid content. There are only a limited number of selectively bred plants that contain more CBC. CBC activates the CB2 receptors, but shows little activity at the CB1 receptor sites. Research shows that CBC may contribute to healthy brain function.

There are three other important cannabinoids called: CBGA. CBN and THCV. But in order not to make this blog too long, let's leave this one aside ;).

The psychoactive cannabinoids
Not all major cannabinoids are psychoactive. To induce these effects, the substance must be able to activate the CB1 receptor. This then results in chemical changes in the central nervous system. It promotes appetite and improves mood. THC,THCV, and CBN all create a somewhat psychoactive effect.

Finally, the cannabinoids that have no psychoactive effect. These are: CBG and maybe the unexpected CBD. Both substances do not bind to the CB1 receptor. In addition, CBD even appears to inhibit the psychoactive effects of THC when consumed together.

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